Gliadin IgG, IgA, IgM ELISA

Parameter Cat. No.

Intended Use:

The Immunolab Gliadin IgG, IgA and IgM Antibody ELISA Test Kits have been designed for the detection and the quantitative determination of specific IgG, IgA and IgM antibodies to Gliadin in serum and plasma.

General Info:

Gliadin is the main component of the protein gluten, which occurs in wheat and other domestic grain types. It leads to severe diseases of the intestinal mucosa in sensitive children and adults. Celiac disease, a gluten-induced enteropathy, appears rather frequently (1 case on 300 births). By the toxic effect of gluten in the intestinal tract, anti­bodies, cytokines and lymphocytes are released. Celiac disease causes villous atrophy leading to permanent malabsorptions of nutrients. Clinical symptoms are weight loss, diarrhea, flatulence and abdominal pain. Serological methods for the determination of IgG and IgA antibodies against gliadin in the patient serum are increasingly used as a screening method. Anti-Gliadin titers are used as a marker of the condition of the small intestine mucous membrane. A gluten-free diet results in a decrease of the antibody titer and leads to a remission of the disease. The detection of antibodies is also well suited for the monitoring of patients after a gluten-free diet.