|Thyroid Peroxidase IgG ELISA||ILE-TPG01|
The Immunolab Thyroid Peroxidase IgG Antibody ELISA Test Kit has been designed for the detection and the quantitative determination of specific IgG antibodies (anti-TPO) against Thyroid Peroxidase in serum and plasma.
Thyroid peroxidase (TPO) is a protein located in the cell membrane of thyroid cells. It is the main antigen found in thyroid microsomes. Like Thyroglobulin it plays a major role for the production of thyroid hormones by regulating the iodisation of tyrosine residues in thyroglobulin. The inhibition of TPO by specific autoantibodies leads to a reduced hormone production resulting in hypothyroidosis. Autoantibodies to TPO and TG are often detected together because of their close functionality. Autoantibodies to TPO are associated with both Hashimoto’s thyroiditis and Graves’ (Basedow’s) disease. In rare cases low concentrations of TPO antibodies are also found in healthy people of advanced age.