Borrelia burgdorferi, the causative agent of Lyme-Borreliosis, belongs to the family of spirochetes. The naming refers to W. Burgdorfer, who discovered this pathogen in 1982. The most important human pathogen genospecies B. burgdorferi sensu stricto, B. garinii and B. afzelii are represented by the Borrelia antigen used in this kit.
Borrelia are transmitted to humans by infected ticks (Ixodes ricinus, Europe; Ixodes scapularis, USA). The incubation period varies from 3 to 30 days. The clinical course of a borreliosis can be divided into three stages starting with Erythema migrans followed by influenza-like symptoms, Lyme-arthritis and/or neuroborreliosis. The course of the disease can widely vary though from patient to patient.
The Immunolab Borrelia burgdorferi IgG/IgM/IgA ELISAs are quantitative and qualitative tests for the detection of human antibodies to Borrelia burgdorferi in serum and plasma. The serological diagnosis is often difficult, as no antibodies can be detected in 50-60% (stage I) and 10-30% (stage II) of the cases while there is a manifest disease. High antibody titers can be almost always detected in stage III. Further, an early antibiotic therapy can suppress the formation of antibodies.
Features of Immunolab ELISA kits: