The Epstein-Barr Virus (EBV) belongs to the group of herpes viruses (HHV4). EBV is EBV is ubiquitous and leads to persistent infection of its host. Adults show a high seroprevalence of 90-95%. EBV is the causative agent of infectious mononucleosis (kissing disease, Pfeiffer disease) which is characterized by fever and a swelling of the lymph nodes, typically accompanied by tonsillitis and pharyngitis. EBV is also implicated in malignant diseases (including Burkitt lymphomy) and nasopharyngeal carcinomas. In developing countries primary infection occurs during the first years and mainly progresses asymptomatically. In countries with good hygienic conditions primary infection is delayed and mostly affects the group of 12 and 20 years of age. About 50% of the infected individuals develop the clinical picture of infectious mononucleosis. EBV is excreted in saliva and pharyngeal secretions. It is transmitted by close contact like kissing (“kissing disease”). The incubation period can be up to 8 weeks.
The Immunolab Epstein-Barr (EBV) EA, EBNA and VCA IgG/IgA/IgM ELISAs are quantitative and qualitative tests for the detection of human antibodies to EBV in serum and plasma. EBV EA IgG and VCA IgM ELISA tests are used for the detection of an acute infection and and relapse (reactivation), respectively. The EBV VCA IgG ELISA is used for the determination of a primary or previous infection. EBNA1 antibodies appear lately and as such are used to detect a previous infection, especially in case of missing VCA IgM antibodies.
Features of Immunolab ELISA kits: