Herpes simplex 1/2 (HSV1/2)  ELISA

Herpes simplex Virus (HSV) types 1 and 2 are ubiquitous. In industrialized countries the infection rate of HSV1 and HSV2 is 90% and 10-15%, respectively. HSV1 is transmitted by contact (kissing) and in rare cases by smear infection. Primary infection with HSV1 occurs in early childhood. The virus causes mostly oro-facial lesions like Herpes labialis as well as other infection in the face and head area. Possible complications include keratoconjunctivitis and a severe form of encephalitis. HSV1 persists in the latent state in the trigeminal ganglion. Reactivations are triggered by endogenous and exogenous factors. HSV2 is transmitted by sexual contacts. The virus usually affects the urogenital area and is the causative agent of Herpes genitalis and contributor of Herpes neonatorum. HSV2 persists in the latent state in the lumbosacral ganglia or periphel tissues. Many herpes infections remain in a preclinical stage while IgG antibodies can be detected in the sera of nearly 100% of the affected people. A differentiation between primary infection and reactivation is important during pregnancy. Most HSV1 and HSV2 antigens show a high grade of cross-reactivity. A serological differentiation is only possible by the detection of antibodies to HSV glycoprotein G.

The Immunolab Herpes simplex (HSV) 1, 2 and 1/2 IgG/IgA/IgM ELISAs are quantitative and qualitative tests for the detection of human antibodies to HSV 1, 2 and 1/2 in serum and plasma. IgM antibodies are only produced during the asymptomatic primary infection. In later stages only IgG antibodies can be detected. The IgA ELISA is specially used for the detection of reactivations. In case of chronical and recurrent infections IgG and IgA titers are used to monitor the course of a therapy. 

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