The TBE (tick-borne encephalitis) virus belongs to the genus of Flaviviruses. There are 3 subtypes: (a) Western European subtype transmitted by the tick Ixodes ricinus (b) Siberian subtype transmitted by the tick Ixodes persulcatus (c) Far Eastern subtype transmitted by the tick Ixodes persulcatus. The European TBE appears in many countries of Middle, Eastern and Northern Europe. The virus is transmitted by tick bites and in rare cases by ingestion of non-pasteurized milk or milk products. The infection occurs mainly in rural and wooded regions from May to September. Most infections progress subclinically. In case of clinically relevant infections influenza-like symptoms like fever, headache and body aches appear firstly after about one week. The second phase starts after another week and is associated by high fever and CNS infestation. The acute meningitis occurs predominantly in children. It mostly heals without any late effects. The letality is about 1%. There is no casual treatment for TBE. Meanwhile an active vaccination is recommended as preventive action when moving in risk regions.
The Immunolab TBEV IgG and IgM ELISAs are quantitative and qualitative tests for the detection of human antibodies to TBE viruses in human sera and plasma. The ELISA allows a reliable determination of a TBEV infection. A positive IgM result as well as a significant titer increase of a serum pair prove an acute infection. The IgG detection can be used to monitor a vaccination.
Features of Immunolab ELISA kits: