The Varicella zoster virus (VZV) belongs to the group of herpes viruses (HHV3). VZV is ubiquitous. It causes chickenpox in case of an exogenous primary infection and shingles (zoster) in case of an endogenous reactivation. VZV is a highly contagious agent which is transmitted by contact to the infective vesicles as well as aerogenically by droplets. Chickenpox is a frequent childhood disease which is associated by fever, body aches and vesicular skin lesions. About 2 weeks after the infection the typical vesicular rash (chickenpox) starts. After a reactivation of the enogenous virus, shingles is developed, as localized, painful, vesicular reddening. The rate of infection increases significantly from the 3. year of age and reaches 90% in adulthood. After the infection the virus enters sensorial ganglions of the spinal cord where it persists for life in the organism. Like all herpes viruses VZV causes a lifelong persistence.
The Immunolab Varizella IgG/IgA/IgM ELISAs are quantitative and qualitative tests for the detection of human antibodies to the Varicella virus in serum or plasma. The IgM ELISA is used as a detection of anacute infection. The separate detection of the 3 immunoglobulin classes using an ELISA enables a differentiation between acute and previous infections.
Features of Immunolab ELISA kits: